The airstrike reportedly killed Mohammad Reza Zahedi, a senior Iranian Revolutionary Guards Corps (IRGC) commander.
Iranian President Ebrahim Raisi threatened that Israel would pay a heavy price for the attack.
IDF Spokesperson R.-Adm. Daniel Hagari emphasized that Israels military is prepared for various scenarios and remains on high alert.
Israels campaign against Iranian-linked targets in Syria has been ongoing for over a decade, aiming to degrade Iranian militia groups.
Israels strikes on Iranian targets have intensified since the start of the conflict in Gaza.
Lt. Gen. Alexus Grynkewich expressed concern that the airstrike on Irans consulate in Syria could lead to renewed attacks on U.S. bases in Iraq and Syria.
Iranian officials have vowed swift retaliation, likely through their network of terrorist proxies such as Hamas, Houthis, and Hezbollah.
Israels direct strike on the Iranian consulate in Damascus is seen as an escalation, despite the countrys involvement in conflicts in Gaza and Lebanon.